Welcome to the Chris Vakoc Lab

Chromatin biology

Cancer therapeutics

Transcriptional regulation

Our laboratory studies how transcription factors and chromatin regulators cooperate to maintain the cancer cell state. We use a combination of genetically-engineered mouse cancer models, CRISPR-Cas9 genetic screens, epigenomics, and biochemical approaches to reveal gene regulatory mechanisms. A primary research objective is to develop transcriptional regulators as next-generation drug targets in oncology.