The Vakoc Lab: Cancer Epigenetics Research

Co-dependencies of fusion oncoproteins

Coactivator vulnerabilities in acute myeloid leukemia

Epigenetic regulation of pancreatic cancer metastasis

Signal transduction to chromatin

Small cell lung cancer epigenetics

Domain-focused CRISPR screening

Our laboratory studies how transcription factors and chromatin regulators cooperate to maintain the cancer cell state. We use genetically-engineered mouse cancer models, CRISPR-Cas9 genetic screens, epigenomics, and biochemical approaches to reveal gene regulatory mechanisms. Our long-term research objective is to develop transcriptional regulators as next-generation drug targets in oncology.