Welcome to the Chris Vakoc Lab

Chromatin biology

Cancer therapeutics

Transcriptional regulation

Our laboratory studies how transcription factors and chromatin regulators cooperate to maintain the cancer cell state. We use genetically-engineered mouse cancer models, CRISPR-Cas9 genetic screens, epigenomics, and biochemical approaches to reveal gene regulatory mechanisms. A primary research objective is to develop transcriptional regulators as next-generation drug targets in oncology.